| Kerosene (lamp fuel refined from coal and later oil), 1846 | Abraham Gesner, Nova Scotia | cleaner, cheaper light than whale oil or candles |
| Automatic lubricator for steam engines, patented 1872 | Elijah McCoy, born in Colchester, Ontario | oiled engines while they ran, so trains did not have to stop |
| Standard time zones, proposed 1879 | Sandford Fleming, railway engineer | one clear time system for railway schedules across a huge country |
| Insulin as a treatment for diabetes, 1921–22 | Frederick Banting, Charles Best, James Collip and J. J. R. Macleod, University of Toronto | a treatment for type 1 diabetes, which was then fatal |
| B7 snowmobile, 1937 (the smaller Ski-Doo followed in 1959) | Joseph-Armand Bombardier, Valcourt, Quebec | travel over deep snow in rural Quebec in winter |
| External heart pacemaker, 1950 | Wilfred Bigelow, John Callaghan and engineer John Hopps (National Research Council) | controlling the heartbeat during heart surgery |
| Electric wheelchair, 1950s | George Klein, National Research Council | independence for veterans and others with quadriplegia |
| Canadarm, first flown 1981 | Spar Aerospace and the National Research Council with Canadian engineers | moving cargo and astronauts in space |